Cross-feeding between<i>Bifidobacterium infantis</i>and<i>Anaerostipes caccae</i>on lactose and human milk oligosaccharides
نویسندگان
چکیده
The establishment of the gut microbiota immediately after birth is a dynamic process that may impact lifelong health. At this important developmental stage in early life, human milk oligosaccharides (HMOs) serve as specific substrates to shape nursling. well-orchestrated transition an aberrant microbial composition and bacterial-derived metabolites are associated with colicky symptoms atopic diseases infants. Here, we study trophic interactions between HMO-degrader, Bifidobacterium infantis butyrogenic Anaerostipes caccae using carbohydrate relevant life period including lactose total carbohydrates. Mono- co-cultures these bacterial species were grown at pH 6.5 anaerobic bioreactors supplemented or A. was not able grow on except when co-culture B. infantis, leading growth concomitant butyrate production. Two levels cross-feeding observed, which utilised liberated monosaccharides well lactate acetate produced by infantis. This points towards key ecological role bifidobacteria providing for other will colonise infant gut. progressive shift contributes gradual production could be host-microbial crosstalk maturation.
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ژورنال
عنوان ژورنال: Beneficial Microbes
سال: 2021
ISSN: ['1876-2883', '1876-2891']
DOI: https://doi.org/10.3920/bm2020.0005